I've just got started with this blog. Give it time and I hope to create a really helpful resource for everyone out there sitting the exam. Please feel free to e-mail suggestions and 'killer' revision notes. Thanks. I would love to hear from you about this blog. Please post a comment.

A little disclaimer: I am doing this blog to hopefully help you when revising due to the very little available information about this exam. I am not affiliated with any organisation in doing this, completely unfunded and not being sponsored. I can not guarantee the accuracy of the information, but will do my best. If you think something is incorrect please let me know so we can all learn. Thanks

Saturday, 2 July 2011


I think the following will be useful to learn:

  • Cisplatin can lead to renal damage which can therefore reduce the renal clearance of methotrexate
  • If cisplatin is given before topotecan, exposue to topotecan increases, due to reduced renal clearance of topotecan
  • Allopurinol reduces the metabolic inactivation of 6-mercaptopurine and increases its toxicity.
  • Penicillins, Probenacid and sulfonamides and NSAIDs reduce the renal clearance of Methotrexate. Compete for the tubular secretion pathway
  • If Carboplatin/Cisplatin are administered simultaneously with paclitaxel there is less myelosuppression compared to when platinum preceeds paclitaxel.
  • There is increased neurotoxicity when cisplatin ans paclitaxel are administered together. This interaction is worse when paclitaxel infusion has along duration.

  • Methotrexate can be displaced from Albumin by 1.sulphonamides 2.tetracycline 3.chloramphenicol 4.phenytoin 5.NSAIDs. This will increase the plasma concentration, causing more side effects such as mucositis and myelosuppression


Anonymous said...

great job

Pritish said...

Dear Dr Stephen.

Many thanks for all your time and effort in designing this website.

I was hoping to get in touch with you via email