I think the following will be useful to learn:
- Cisplatin can lead to renal damage which can therefore reduce the renal clearance of methotrexate
- If cisplatin is given before topotecan, exposue to topotecan increases, due to reduced renal clearance of topotecan
- Allopurinol reduces the metabolic inactivation of 6-mercaptopurine and increases its toxicity.
- Penicillins, Probenacid and sulfonamides and NSAIDs reduce the renal clearance of Methotrexate. Compete for the tubular secretion pathway
- If Carboplatin/Cisplatin are administered simultaneously with paclitaxel there is less myelosuppression compared to when platinum preceeds paclitaxel.
- There is increased neurotoxicity when cisplatin ans paclitaxel are administered together. This interaction is worse when paclitaxel infusion has along duration.
- Methotrexate can be displaced from Albumin by 1.sulphonamides 2.tetracycline 3.chloramphenicol 4.phenytoin 5.NSAIDs. This will increase the plasma concentration, causing more side effects such as mucositis and myelosuppression
2 comments:
great job
Dear Dr Stephen.
Many thanks for all your time and effort in designing this website.
I was hoping to get in touch with you via email
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